Synthesis and structure-activity relationships of cerebroside analogues as substrates of cerebroside sulphotransferase and discovery of a competitive inhibitor

Metachromatic leukodystrophy (MLD) is a rare genetic disease characterised by a dysfunction of the enzyme arylsulphatase A leading to the lysosomal accumulation of cerebroside sulphate (sulphatide) causing subsequent demyelination in patients. The enzyme galactosylceramide (cerebroside) sulphotransf...

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Detalhes bibliográficos

Principais autores:	Wenjin Li, Joren Guillaume, Younis Baqi, Isabell Wachsmann, Volkmar Gieselmann, Serge Van Calenbergh, Christa E. Müller
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis Group 2020-01-01
coleção:	Journal of Enzyme Inhibition and Medicinal Chemistry
Assuntos:	capillary electrophoresis (ce) galactosylceramide sulphotransferase (cst) enzyme assay metachromatic leukodystrophy (mld) competitative inhibitor galactosyl ceramide analogues
Acesso em linha:	http://dx.doi.org/10.1080/14756366.2020.1791841
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