Lessons learned from a candidate gene study investigating aromatase inhibitor treatment outcome in breast cancer

Abstract The role of germline genetics in adjuvant aromatase inhibitor (AI) treatment efficacy in ER-positive breast cancer is poorly understood. We employed a two-stage candidate gene approach to examine associations between survival endpoints and common germline variants in 753 endocrine resistanc...

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Главные авторы:	Reiner Hoppe, Stefan Winter, Wing-Yee Lo, Kyriaki Michailidou, Manjeet K. Bolla, Renske Keeman, Qin Wang, Joe Dennis, Michael Lush, Krishna R. Kalari, Matthew P. Goetz, Liewei Wang, Junmei Cairns, Richard Weinshilboum, Lois Shepherd, Bingshu E. Chen, Lothar Häberle, Matthias Ruebner, Matthias W. Beckmann, Wei He, Nicole L. Larson, Sebastian M. Armasu, Werner Schroth, Balram Chowbay, Chiea Chuen Khor, Mustapha Abubakar, Antonis C. Antoniou, Thomas Brüning, Jose E. Castelao, Jenny Chang-Claude, NBCS Collaborators, Thilo Dörk, Diana M. Eccles, Jonine D. Figueroa, Manuela Gago-Dominguez, José A. García-Sáenz, Melanie Gündert, Carolin C. Hack, Ute Hamann, Sileny Han, Maartje J. Hooning, Hanna Huebner, ABCTB Investigators, Esther M. John, Yon-Dschun Ko, Vessela N. Kristensen, Sabine Linn, Sara Margolin, Dimitrios Mavroudis, Heli Nevanlinna, Patrick Neven, Nadia Obi, Tjoung-Won Park-Simon, Katri Pylkäs, Muhammad U. Rashid, Atocha Romero, Emmanouil Saloustros, Elinor J. Sawyer, William J. Tapper, Ian Tomlinson, Camilla Wendt, Robert Winqvist, Alison M. Dunning, Jacques Simard, Per Hall, Paul D. P. Pharoah, Matthias Schwab, Fergus J. Couch, Kamila Czene, Peter A. Fasching, Douglas F. Easton, Marjanka K. Schmidt, James N. Ingle, Hiltrud Brauch
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Nature Portfolio 2025-02-01
Серии:	npj Breast Cancer
Online-ссылка:	https://doi.org/10.1038/s41523-025-00733-y
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