Hedgehog signaling is a potent regulator of liver lipid metabolism and reveals a GLI-code associated with steatosis

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in industrialized countries and is increasing in prevalence. The pathomechanisms, however, are poorly understood. This study assessed the unexpected role of the Hedgehog pathway in adult liver lipid metabolism. Using transgen...

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Autors principals:	Madlen Matz-Soja, Christiane Rennert, Kristin Schönefeld, Susanne Aleithe, Jan Boettger, Wolfgang Schmidt-Heck, Thomas S Weiss, Amalya Hovhannisyan, Sebastian Zellmer, Nora Klöting, Angela Schulz, Jürgen Kratzsch, Reinhardt Guthke, Rolf Gebhardt
Format:	Artigo
Idioma:	Inglês
Publicat:	eLife Sciences Publications Ltd 2016-05-01
Col·lecció:	eLife
Matèries:	Hedgehog signalling hepatocytes liver NAFLD steatotic Gli-code smoothened
Accés en línia:	https://elifesciences.org/articles/13308
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