Synthetic Prostacyclin Agonist Attenuates Pressure-Overloaded Cardiac Fibrosis by Inhibiting FMT

Fibroblast-to-myofibroblast transition (FMT) is the primary inducer of cardiac fibrosis. ONO-1301, a synthetic prostacyclin agonist, reportedly promotes tissue fibrosis repair by enhancing anti-fibrotic cytokine production. We hypothesized that ONO-1301 attenuates pressure-overloaded cardiac fibrosi...

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Detalhes bibliográficos

Principais autores:	Kenta Masada, Shigeru Miyagawa, Yoshiki Sakai, Akima Harada, Tomomitsu Kanaya, Yoshiki Sawa
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2020-12-01
Colecção:	Molecular Therapy: Methods & Clinical Development
Assuntos:	ONO-1301 prostacyclin cardiac fibrosis fibroblast
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S232905012030190X
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