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Aberrant Epithelial Differentiation Contributes to Pathogenesis in a Murine Model of Congenital Tufting EnteropathySummary

Background & Aims: Congenital tufting enteropathy (CTE) is an intractable diarrheal disease of infancy caused by mutations of epithelial cell adhesion molecule (EpCAM). The cellular and molecular basis of CTE pathology has been elusive. We hypothesized that the loss of EpCAM in CTE results in al...

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Principais autores: Barun Das, Kevin Okamoto, John Rabalais, Jocelyn A. Young, Kim E. Barrett, Mamata Sivagnanam
פורמט: Artigo
שפה:Inglês
יצא לאור: Elsevier 2021-01-01
סדרה:Cellular and Molecular Gastroenterology and Hepatology
נושאים:
Congenital Tufting Enteropathy
Intestinal Cell Differentiation
Intestinal Failure
EpCAM
Defective Enterocyte
Congenital Diarrhea
גישה מקוונת:http://www.sciencedirect.com/science/article/pii/S2352345X21001302
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