Early and progressive retinal microglial changes in APPNL-F/NL-F mouse model of Alzheimer’s disease revealed by an automated image analysis software

Alzheimer’s disease (AD) is characterized by the accumulation of misfolded proteins that trigger neuroinflammation and neuronal loss. The retina, as an extension of the central nervous system, mirrors these pathological processes and represents a potential biomarker. Microglial activation, a key com...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Lidia Sánchez-Puebla, Inés López-Cuenca, Miguel A. Sánchez-Puebla, Ana Granados, Ana I. Ramírez, Juan Llorens, Takaomi C. Saido, Takashi Saito, Carmen Nieto-Vaquero, María A. Moro, Valentín Moreno, José M. Ramírez, Rosa de Hoz
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2026-01-01
Schriftenreihe:	Frontiers in Aging Neuroscience
Schlagworte:	Alzheimer’s disease APPNL-F/NL-F mouse model automated image analysis morphological quantification neuroinflammation retinal microglia
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fnagi.2025.1712480/full
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