Safety and Effectiveness of Direct Oral Anticoagulants in Combination with Antiseizure Medications: Protocol for a Systematic Review and Meta-analysis

Abstract Introduction The concurrent use of direct oral anticoagulants (DOACs) and antiseizure medications (ASMs) is increasingly common, particularly among patients with atrial fibrillation, stroke, and epilepsy. Certain ASMs may affect the pharmacokinetics of DOACs through enzyme induction or modu...

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Autori principali:	Kai Michael Schubert, Johan Zelano, David J. Seiffge, Francesco Brigo, Eugen Trinka, Nishant K. Mishra, Emilio Russo, Marian Galovic
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Adis, Springer Healthcare 2025-10-01
Serie:	Neurology and Therapy
Soggetti:	Direct oral anticoagulants DOAC Antiseizure medications Antiepileptic drugs ASM Drug–drug interactions
Accesso online:	https://doi.org/10.1007/s40120-025-00836-5
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