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High levels of tumor cell-intrinsic STING signaling are associated with increased infiltration of CD8+ T cells in dMMR/MSI-H gastric cancer

Abstract Mismatch repair deficient (dMMR)/microsatellite instability-high (MSI-H) gastric cancer (GC) exhibits an immune-active tumor microenvironment (TME) compared to MMR proficient (pMMR)/microsatellite stable/Epstein-Barr virus-negative [EBV (−)] GC. The tumor cell-intrinsic cyclic GMP–AMP synth...

Deskribapen osoa

Gorde:
Egile Nagusiak: Ryo Kanoda, Shotaro Nakajima, Satoshi Fukai, Motonobu Saito, Katsuharu Saito, Hiroya Suzuki, Tomohiro Kikuchi, Azuma Nirei, Hirokazu Okayama, Kosaku Mimura, Hiroyuki Hanayama, Wataru Sakamoto, Tomoyuki Momma, Zenichiro Saze, Koji Kono
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Portfolio 2024-09-01
Saila:Scientific Reports
Gaiak:
Gastric cancer
Mismatch repair deficient
Cyclic GMP–AMP synthase–stimulator of interferon genes
CD8+ tumor-infiltrating lymphocytes
Tumor microenvironment
Sarrera elektronikoa:https://doi.org/10.1038/s41598-024-71974-3
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