Artificial microRNAs targeting tau enable post-symptomatic functional recovery in aged tauopathy mice

Tauopathies are a group of neurodegenerative disorders, including Alzheimer’s disease, frontotemporal dementia, and progressive supranuclear palsy, characterized by the pathological accumulation of tau protein. While tau reduction has emerged as a promising disease-modifying strategy, most preclinic...

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Главные авторы:	Carolina Lucía Facal, Indiana Páez-Paz, A. Ezequiel Pereyra, Clara Gaguine, Ramiro Clerici-Delville, Rocío Foltran, Mariano Soiza-Reilly, María Elena Avale
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Elsevier 2026-03-01
Серии:	Molecular Therapy: Nucleic Acids
Предметы:	MT: Clinical Applications gene therapy RNA therapy microRNAs artificial microRNAs tau
Online-ссылка:	http://www.sciencedirect.com/science/article/pii/S2162253126000144
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