The conformation of the nSrc specificity-determining loop in the Src SH3 domain is modulated by a WX conserved sequence motif found in SH3 domains

Cellular signaling networks are modulated by multiple protein-protein interaction domains that coordinate extracellular inputs and processes to regulate cellular processes. Several of these domains recognize short linear motifs, or SLiMs, which are often highly conserved and are closely regulated. O...

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Autori principali:	Frederick Longshore-Neate, Caroline Ceravolo, Cole Masuga, Elise F. Tahti, Jadon M. Blount, Sarah N. Smith, Jeanine F. Amacher
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2024-12-01
Serie:	Frontiers in Molecular Biosciences
Soggetti:	SH3 domains protein-protein interactions protein-peptide interactions short linear motifs specificity signal transduction
Accesso online:	https://www.frontiersin.org/articles/10.3389/fmolb.2024.1487276/full
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