Anti‐PD‐1/Her2 Bispecific Antibody IBI315 Enhances the Treatment Effect of Her2‐Positive Gastric Cancer through Gasdermin B‐Cleavage Induced Pyroptosis

Abstract The majority of patients with human epidermal growth factor receptor 2 (Her2)‐positive gastric cancer develop refractory to Her2‐targeted therapy, where upregulation of immune checkpoints plays an essential role. Herein, a recombinant fully human IgG1 bispecific antibody IBI315 targeting bo...

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Detalhes bibliográficos

Principais autores:	Wu Lin, Yingzi Zhang, Yan Yang, Ben Lin, Mengjia Zhu, Jinling Xu, YiRan Chen, Weiwei Wu, Bingliang Chen, Xiangliu Chen, Jin Liu, Haohao Wang, Fei Teng, Xiongfei Yu, Haiyong Wang, Jun Lu, Quan Zhou, Lisong Teng
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2023-10-01
coleção:	Advanced Science
Assuntos:	bispecific antibodies GSDMB Her2 immunotherapy pyroptosis
Acesso em linha:	https://doi.org/10.1002/advs.202303908
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