An improved fully-automated GMP radiosynthesis of [18F]fluoro-pivalic acid with solid-phase extraction purification

Abstract Background We previously reported the first-in-human evaluation of 3-[18F]-fluoro-2,2-dimethylpropionic acid ([18F]FPIA) for imaging aberrant lipid metabolism and cancer detection. The first-generation semi-automated radiosynthesis of [18F]FPIA required HPLC purification to provide injectio...

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Autors principals:	Chris Barnes, Frazer Twyman, Ramla O. Awais, Dylan Pritchard, Matthias Glaser, David R. Turton, Diana Brickute, Graham Smith, Erik Årstad, Louis Allott, Eric O. Aboagye
Format:	Artigo
Idioma:	Inglês
Publicat:	SpringerOpen 2026-03-01
Col·lecció:	EJNMMI Radiopharmacy and Chemistry
Matèries:	[18F]FPIA [18F]fluoropivalic acid GMP radiopharmaceutical Automated radiosynthesis SPE purification PET/positron emission tomography
Accés en línia:	https://doi.org/10.1186/s41181-026-00440-4
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