Allosterically activating SHP2 by oleanolic acid inhibits STAT3–Th17 axis for ameliorating colitis

Src homology 2 domain-containing tyrosine phosphatase 2 (SHP2) is an essential tyrosine phosphatase that is pivotal in regulating various cellular signaling pathways such as cell growth, differentiation, and survival. The activation of SHP2 has been shown to have a therapeutic effect in colitis and...

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Detalhes bibliográficos

Principais autores:	Jinbo Hu, Wen Liu, Yi Zou, Chenyang Jiao, Jiazhen Zhu, Qiang Xu, Jianjun Zou, Yang Sun, Wenjie Guo
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2024-06-01
Colecção:	Acta Pharmaceutica Sinica B
Assuntos:	Oleanolic acid SHP2 STAT3 Th17 Colitis Allosteric activator
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211383524000972
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