Multistep Synthesis and In Vitro Anticancer Evaluation of 2-Pyrazolyl-Estradiol Derivatives, Pyrazolocoumarin-Estradiol Hybrids and Analogous Compounds

Although the hormone independent cytotoxic activity of several estradiol derivatives endowed with a simple substituent at C-2 has been reported so far, 2-heterocyclic and 2,3-condensed analogs are less investigated from both synthetic and pharmacological points of view. Therefore, novel A-ring-conne...

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Principais autores:	Barnabás Molnár, Mohana Krishna Gopisetty, Dóra Izabella Adamecz, Mónika Kiricsi, Éva Frank
Format:	Artigo
Jezik:	Inglês
Izdano:	MDPI AG 2020-09-01
Serija:	Molecules
Teme:	steroids heterocyclic estradiol derivatives Friedel-Crafts acetylation arylhydrazones Vilsmeier-Haack reaction 4-formyl-pyrazoles
Online dostop:	https://www.mdpi.com/1420-3049/25/18/4039
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