Sequential omics analysis reveals molecular signatures of malignant transformation in recurrent meningiomas

Abstract Meningiomas are the most common primary brain tumors in adults and have the potential for recurrence. Although most recurrent meningiomas retain their initial World Health Organization grade, a subset undergoes malignant transformation (MT). The molecular mechanisms underlying this transfor...

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Үндсэн зохиолчид:	Kenta Ohara, Satoru Miyawaki, Yu Teranishi, Daisuke Komura, Atsushi Okano, Hiroki Hongo, Shogo Dofuku, Daiichiro Ishigami, Yu Sakai, Daisuke Shimada, Hiroto Katoh, Genta Nagae, Masako Ikemura, Tetsuo Ushiku, Shinichi Morishita, Yutaka Suzuki, Masahiro Shin, Hirofumi Nakatomi, Shumpei Ishikawa, Hiroyuki Aburatani, Nobuhito Saito
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	BMC 2025-11-01
Цуврал:	Acta Neuropathologica Communications
Нөхцлүүд:	Recurrent meningioma World Health Organization grade Malignant transformation Grade-retained recurrence Molecular classification
Онлайн хандалт:	https://doi.org/10.1186/s40478-025-02149-y
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