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NDUFS4, a mitochondrial complex I subunit, is essential for T-cell metabolic fitness and immune function

IntroductionMitochondrial metabolism is essential for T-cell function, but the roles of individual electron transport chain (ETC) components are unclear. Here, we aimed to explore the role of mitochondrial complex I (CI) subunit NADH:ubiquinone oxidoreductase iron-sulfur protein 4 (NDUFS4) in T-cell...

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Principais autores: Oded Shamriz, Zahala Bar-On, Omri Yosef, Leonor Cohen-Daniel, Ayelet Sheer, Or Reuven, Wajeeh Salaymeh, Amijai Saragovi, Raz Somech, Atar Lev, Hagar Mor-Shaked, Yuval Tal, Aviva Fattal-Valevski, Simon Edvardson, Michael Berger
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-01-01
coleção:Frontiers in Immunology
Assuntos:
leigh syndrome (LS)
mitochondria
NDUFS4
NDUFS4 knockout mice
T cells
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1734203/full
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