Immunomodulation targeting abnormal protein conformation reduces pathology in a mouse model of Alzheimer's disease.

Many neurodegenerative diseases are characterized by the conformational change of normal self-proteins into amyloidogenic, pathological conformers, which share structural properties such as high β-sheet content and resistance to degradation. The most common is Alzheimer's disease (AD) where the norm...

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Autores principales:	Fernando Goñi, Frances Prelli, Yong Ji, Henrieta Scholtzova, Jing Yang, Yanjie Sun, Feng-Xia Liang, Regina Kascsak, Richard Kascsak, Pankaj Mehta, Thomas Wisniewski
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Public Library of Science (PLoS) 2010-10-01
Colección:	PLoS ONE
Acceso en línea:	https://doi.org/10.1371/journal.pone.0013391
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