A Synthetic Cross-Species CD200R1 Agonist Suppresses Inflammatory Immune Responses In Vivo

Functional aptamers displaying agonistic or antagonistic properties are showing great promise as modulators of immune responses. Here, we report the development of a polyethylene glycol-modified (PEGylated) DNA aptamer as a cross-species (murine and human) CD200R1 agonist that modulates inflammatory...

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Detalhes bibliográficos

Principais autores:	Aaron Prodeus, Amanda Sparkes, Nicholas W. Fischer, Marzena Cydzik, Eric Huang, Ismat Khatri, Ashley Young, Lindsay Woo, Chung Wai Chow, Reginald Gorczynski, Jean Gariépy
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2018-09-01
coleção:	Molecular Therapy: Nucleic Acids
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2162253118301239
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