Letrozole treatment of adult female mice results in a similar reproductive phenotype but distinct changes in metabolism and the gut microbiome compared to pubertal mice

Abstract Background A majority of women with polycystic ovary syndrome (PCOS) have metabolic dysfunction that results in an increased risk of type 2 diabetes. We previously developed a pubertal mouse model using the aromatase inhibitor, letrozole, which recapitulates many of the reproductive and met...

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Ngā kaituhi matua:	Pedro J. Torres, Danalea V. Skarra, Bryan S. Ho, Lillian Sau, Arya R. Anvar, Scott T. Kelley, Varykina G. Thackray
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	BMC 2019-03-01
Rangatū:	BMC Microbiology
Ngā marau:	Gut microbiome Polycystic ovary syndrome Hyperandrogenism Puberty
Urunga tuihono:	http://link.springer.com/article/10.1186/s12866-019-1425-7
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!