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Wolf-Hirschhorn Syndrome Candidate 1 Is Necessary for Correct Hematopoietic and B Cell Development

Immunodeficiency is one of the most important causes of mortality associated with Wolf-Hirschhorn syndrome (WHS), a severe rare disease originated by a deletion in chromosome 4p. The WHS candidate 1 (WHSC1) gene has been proposed as one of the main genes responsible for many of the alterations in WH...

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Autors principals: Elena Campos-Sanchez, Nerea Deleyto-Seldas, Veronica Dominguez, Enrique Carrillo-de-Santa-Pau, Kiyoe Ura, Pedro P. Rocha, JungHyun Kim, Arafat Aljoufi, Anna Esteve-Codina, Marc Dabad, Marta Gut, Holger Heyn, Yasufumi Kaneda, Keisuke Nimura, Jane A. Skok, Maria Luisa Martinez-Frias, Cesar Cobaleda
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2017-05-01
Col·lecció:Cell Reports
Matèries:
Wolf-Hirschhorn syndrome
immunodeficiency
B cell development
hematopoiesis
hematopoietic stem cells
class-switch recombination
H3K36 methylation
replicative stress
cell cycle
Accés en línia:http://www.sciencedirect.com/science/article/pii/S2211124717305983
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