Single-molecule imaging of Tau reveals how phosphorylation affects its movement and confinement in living cells

Abstract Tau is a microtubule-associated protein that is regulated by post-translational modifications. The most studied of these modifications is phosphorylation, which affects Tau’s aggregation and loss- and gain-of-functions, including the interaction with microtubules, in Alzheimer’s disease and...

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Hlavní autoři:	Pranesh Padmanabhan, Andrew Kneynsberg, Esteban Cruz, Adam Briner, Jürgen Götz
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2024-02-01
Edice:	Molecular Brain
Témata:	Tau Super-resolution microscopy Phosphorylation Single-molecule imaging Microtubules Tauopathies
On-line přístup:	https://doi.org/10.1186/s13041-024-01078-6
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