A human forebrain organoid model reveals the essential function of GTF2IRD1-TTR-ERK axis for the neurodevelopmental deficits of Williams syndrome

Williams syndrome (WS; OMIM#194050) is a rare disorder, which is caused by the microdeletion of one copy of 25–27 genes, and WS patients display diverse neuronal deficits. Although remarkable progresses have been achieved, the mechanisms for these distinct deficits are still largely unknown. Here, w...

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Detalhes bibliográficos

Principais autores:	Xingsen Zhao, Qihang Sun, Yikai Shou, Weijun Chen, Mengxuan Wang, Wenzheng Qu, Xiaoli Huang, Ying Li, Chao Wang, Yan Gu, Chai Ji, Qiang Shu, Xuekun Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	eLife Sciences Publications Ltd 2024-12-01
coleção:	eLife
Assuntos:	Williams syndrome forebrain organoid neurogenesis Gtf2ird1 transthyretin ERK
Acesso em linha:	https://elifesciences.org/articles/98081
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