CHIP ameliorates nonalcoholic fatty liver disease via promoting K63- and K27-linked STX17 ubiquitination to facilitate autophagosome-lysosome fusion

Abstract The fusion of autophagosomes and lysosomes is essential for the prevention of nonalcoholic fatty liver disease (NAFLD). Here, we generate a hepatocyte-specific CHIP knockout (H-KO) mouse model that develops NAFLD more rapidly in response to a high-fat diet (HFD) or high-fat, high-fructose d...

Cijeli opis

Bibliografski detalji

Glavni autori:	Hyunjin Rho, Seungyeon Kim, Seung Up Kim, Jeong Won Kim, Sang Hoon Lee, Sang Hoon Park, Freddy E. Escorcia, Joon-Yong Chung, Jaewhan Song
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Portfolio 2024-10-01
Serija:	Nature Communications
Online pristup:	https://doi.org/10.1038/s41467-024-53002-0
Oznake:	Dodaj oznaku Bez oznaka, Budi prvi tko označuje ovaj zapis!