Formulation of Glibenclamide proniosomes for oral administration: Pharmaceutical and pharmacodynamics evaluation

Glibenclamide (GB), oral antidiabetic sulfonylurea, is used in the management of diabetes mellitus type II. It suffers from low bioavailability due to low water solubility. This work aimed to enhance the dissolution of GB by formulating the drug as a proniosomes which then improves the pharmacologic...

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Detalhes bibliográficos

Principais autores:	Doaa Alshora, Mohamed Ibrahim, Nouf Alanazi, Malak Alowyid, Zainab Ali Alnakhli, Noura Mohammed Alshiban, Saleh Maodaa, Nouf M. Alyami, Ibrahim Alotaibi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Springer 2023-12-01
coleção:	Saudi Pharmaceutical Journal
Assuntos:	Glibenclamide Proniosomes UPLC method Pharmacodynamics study Dissolution enhancement
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S1319016423003250
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