Gradual DNA methylation changes reveal transcription factors implicated in metabolic dysfunction-associated steatotic liver disease progression and epigenetic age acceleration

Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide, but its pathophysiological mechanisms remain elusive. It is a progressive disease, encompassing hepatic steatosis, steatohepatitis with (out) fibrosis, and ultimat...

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Autores principales:	Evelien Van Dijck, Steven Van Laere, Emilie Logie, Steven Timmermans, Erik Fransen, Joe Ibrahim, Timothy J. Kendall, Jonathan A. Fallowfield, Ligia M. Mateiu, Claude Libert, Guy Van Camp, An Verrijken, Luc Van Gaal, Sven Francque, Wim Van Hul, Wim Vanden Berghe
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2025-08-01
Colección:	Clinical Epigenetics
Materias:	MASLD Epigenetics DNA methylation Epigenetic age Epigenetic age acceleration Transcription factor
Acceso en línea:	https://doi.org/10.1186/s13148-025-01945-6
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