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Hyperactivation of Wnt/β-catenin and Jak/Stat3 pathways in human and zebrafish foetal growth restriction models: Implications for pharmacological rescue

Foetal Growth Restriction (FGR), previously known as Intrauterine Growth Restriction (IUGR), is an obstetrical condition due to placental insufficiency, affecting yearly about 30 million newborns worldwide. In this work, we aimed to identify and pharmacologically target signalling pathways specifica...

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Main Authors: Giovanni Risato, Rudy Celeghin, Raquel Brañas Casas, Alberto Dinarello, Alessandro Zuppardo, Andrea Vettori, Kalliopi Pilichou, Gaetano Thiene, Cristina Basso, Francesco Argenton, Silvia Visentin, Erich Cosmi, Natascia Tiso, Giorgia Beffagna
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
foetal growth restriction
intrauterine
hypoxia
zebrafish
Wnt
Stat3
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.943127/full
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