Early recruitment of PARP-dependent m8A RNA methylation at DNA lesions is subsequently accompanied by active DNA demethylation

RNA methylation, especially 6-methyladenosine (m6A)-modified RNAs, plays a specific role in DNA damage response (DDR). Here, we also observe that RNA modified at 8-methyladenosine (m8A) is recruited to UVA-damaged chromatin immediately after microirradiation. Interestingly, the level of m8A RNA at g...

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Detalhes bibliográficos

Principais autores:	Soňa Legartová, Alena Svobodová Kovaříková, Jana Běhalová Suchánková, Hana Polášek-Sedláčková, Eva Bártová
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis Group 2022-12-01
coleção:	RNA Biology
Assuntos:	dna repair epigenetics rna methylation base excision repair dna demethylation
Acesso em linha:	http://dx.doi.org/10.1080/15476286.2022.2139109
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