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CD28/PD1 co-expression: dual impact on CD8+ T cells in peripheral blood and tumor tissue, and its significance in NSCLC patients' survival and ICB response

Abstract Background Immune checkpoint blockade (ICB) has significantly prolonged survival of non-small cell lung cancer (NSCLC) patients, although most patients develop mechanisms of resistance. Recently single-cell RNA-sequencing (scRNA-Seq) revealed a huge T-cell phenotypic and (dys)functional sta...

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Wedi'i Gadw mewn:
Prif Awduron: Belinda Palermo, Ornella Franzese, Giuseppe Frisullo, Lorenzo D’Ambrosio, Mariangela Panetta, Giulia Campo, Daniel D’Andrea, Isabella Sperduti, Francesca De Nicola, Frauke Goeman, Filippo Gallina, Paolo Visca, Francesco Facciolo, Paola Nisticò
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BMC 2023-10-01
Cyfres:Journal of Experimental & Clinical Cancer Research
Pynciau:
Non-small cell lung cancer
CD8+ T cells
PD-1
CD28
T-cell functionality
Single-cell RNA-Seq
Mynediad Ar-lein:https://doi.org/10.1186/s13046-023-02846-3
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