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All-Trans-Retinoic Acid Suppresses Neointimal Hyperplasia and Inhibits Vascular Smooth Muscle Cell Proliferation and Migration via Activation of AMPK Signaling Pathway

The proliferation and migration of vascular smooth muscle cells (VSMC) is extensively involved in pathogenesis of neointimal hyperplasia. All-trans-retinoic acid (ATRA) is a natural metabolite of vitamin A. Here, we investigated the involvement of AMP-activated protein kinase (AMPK) in the anti-neoi...

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Autors principals: Jingzhi Zhang, Bo Deng, Xiaoli Jiang, Min Cai, Ningning Liu, Shuangwei Zhang, Yongzhen Tan, Guiqiong Huang, Wen Jin, Bin Liu, Shiming Liu
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2019-05-01
Col·lecció:Frontiers in Pharmacology
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Accés en línia:https://www.frontiersin.org/article/10.3389/fphar.2019.00485/full
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