Live-cell quantitative monitoring reveals distinct, high-affinity Gβγ regulations of GIRK2 and GIRK1/2 channels

Abstract Gi/o protein-coupled receptors (GPCRs) inhibit cardiac and neuronal excitability via G protein-activated K+ channels (GIRK), assembled by combinations of GIRK1 - GIRK4 subunits. GIRKs are activated by direct binding of the Gβγ dimer of inhibitory Gi/o proteins. However, key aspects of this...

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Auteurs principaux:	Reem Handklo-Jamal, Tal Keren Raifman, Boris Shalomov, Patrick Hofer, Uri Kahanovitch, Theres Friesacher, Galit Tabak, Vladimir Tsemakhovich, Haritha P. Reddy, Orna Chomsky-Hecht, Debi Ranjan Tripathy, Kerstin Zuhlke, Carmen W. Dessauer, Enno Klussmann, Yoni Haitin, Joel A. Hirsch, Anna Stary-Weinzinger, Daniel Yakubovich, Nathan Dascal
Format:	Artigo
Langue:	Inglês
Publié:	Nature Portfolio 2025-11-01
Collection:	Nature Communications
Accès en ligne:	https://doi.org/10.1038/s41467-025-66730-8
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