Cranberry Ingestion Modulated Drug Transporters and Metabolizing Enzymes: Gefitinib Used as a Probe Substrate in Rats

Cranberry, a polyphenol-rich functional food, is commonly used for the prophylaxis of urinary tract infections. Gefitinib, an anticancer agent clinically prescribed to treat non-small-cell lung cancer, is a substrate of P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), and metaboliz...

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Detalhes bibliográficos

Principais autores:	Chung-Ping Yu, Pei-Ling Tsai, Pei-Ying Li, Pei-Wen Hsu, Shiuan-Pey Lin, Pei-Dawn Lee Chao, Yu-Chi Hou
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2022-09-01
coleção:	Molecules
Assuntos:	cranberry gefitinib drug transporter cytochrome P450s pharmacokinetics
Acesso em linha:	https://www.mdpi.com/1420-3049/27/18/5772
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