Tryptophan potentiates CD8+ T cells against cancer cells by TRIP12 tryptophanylation and surface PD-1 downregulation

Background Tryptophan catabolites suppress immunity. Therefore, blocking tryptophan catabolism with indoleamine 2,3-dioxygenase (IDO) inhibitors is pursued as an anticancer strategy.Methods The intracellular level of tryptophan and kynurenine was detected by mass spectrum analysis. The effect of try...

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Detalhes bibliográficos

Principais autores:	Yan Huang, Wei Xu, Chen Zhao, Yan Lin, Yao Li, Rui Qin, Chen-Ji Wang, Jian-Yuan Zhao, Yi-Yuan Yuan, Peng-Cheng Lin, Shimin Zhao
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMJ Publishing Group 2021-07-01
coleção:	Journal for ImmunoTherapy of Cancer
Acesso em linha:	https://jitc.bmj.com/content/9/7/e002840.full
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