Mitochondrial dysfunction by glyoxalase 1 deficiency disrupts definitive endoderm and alveolar development of human pluripotent stem cells

Abstract Normal mitochondrial function is essential for human induced pluripotent stem (hiPS) cell differentiation into definitive endoderm (DE). However, the underlying mechanisms that maintain mitochondrial homeostasis during DE differentiation are not fully elucidated. Here we report that glyoxal...

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Detalhes bibliográficos

Principais autores:	Suji Jeong, Hyebin Koh, Minje Kang, Ji-Young Kim, Roya Rasaei, Woo Jin Kim, Seon-Sook Han, In Sun Hong, Se-Ran Yang, Jong-Hee Lee, Seok-Ho Hong
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2025-09-01
coleção:	Experimental and Molecular Medicine
Acesso em linha:	https://doi.org/10.1038/s12276-025-01524-y
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