Disome-seq reveals widespread ribosome collisions that promote cotranslational protein folding

Abstract Background The folding of proteins is challenging in the highly crowded and sticky environment of a cell. Regulation of translation elongation may play a crucial role in ensuring the correct folding of proteins. Much of our knowledge regarding translation elongation comes from the sequencin...

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Hlavní autoři:	Taolan Zhao, Yan-Ming Chen, Yu Li, Jia Wang, Siyu Chen, Ning Gao, Wenfeng Qian
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2021-01-01
Edice:	Genome Biology
Témata:	Translation elongation Disome-seq Ribosome collision Translational pause Ribosome release Ribosome-associated chaperones
On-line přístup:	https://doi.org/10.1186/s13059-020-02256-0
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