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Germline variant affecting p53β isoforms predisposes to familial cancer

Abstract Germline and somatic TP53 variants play a crucial role during tumorigenesis. However, genetic variations that solely affect the alternatively spliced p53 isoforms, p53β and p53γ, are not fully considered in the molecular diagnosis of Li-Fraumeni syndrome and cancer. In our search for additi...

Deskribapen osoa

Gorde:
Egile Nagusiak: Stephanie A. Schubert, Dina Ruano, Sebastien M. Joruiz, Jordy Stroosma, Nikolina Glavak, Anna Montali, Lia M. Pinto, Mar Rodríguez-Girondo, Daniela Q. C. M. Barge-Schaapveld, Maartje Nielsen, Bernadette P. M. van Nesselrooij, Arjen R. Mensenkamp, Monique E. van Leerdam, Thomas H. Sharp, Hans Morreau, Jean-Christophe Bourdon, Noel F. C. C. de Miranda, Tom van Wezel
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Portfolio 2024-09-01
Saila:Nature Communications
Sarrera elektronikoa:https://doi.org/10.1038/s41467-024-52551-8
Etiketak: Etiketa erantsi
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