Structural insights into the selective recognition of RF-amide peptides by neuropeptide FF receptor 2

Abstract Neuropeptide FF Receptor 2 (NPFFR2), a G-protein-coupled receptor, plays a role in pain modulation and diet-induced thermogenesis. While NPFFR2 is strongly activated by neuropeptides FF (NPFFs), it shows low activity in response to RF-amide-related peptides (RFRPs), despite the peptides bel...

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Hlavní autoři:	Jeesoo Kim, Sooyoung Hong, Hajin Lee, Hyun Sik Lee, Chaehee Park, Jinuk Kim, Wonpil Im, Hee-Jung Choi
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Springer Nature 2025-03-01
Edice:	EMBO Reports
Témata:	RF-amide Peptide Neuropeptide FF Receptors Ligand Selectivity cryo-EM Structure
On-line přístup:	https://doi.org/10.1038/s44319-025-00428-2
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