Pharmacologic targeting of midasin (MDN1) reveals a potential therapeutic vulnerability in ESR1-mutant breast cancer

IntroductionAlthough most cases of estrogen receptor-positive (ER+) breast cancer initially respond to endocrine therapy, many patients ultimately develop resistance. A major contributor to endocrine resistance in metastatic disease is the acquisition of constitutively active somatic mutations in th...

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Principais autores:	Mounika Pamukuntla, Afia Ohemeng, Bipika Banjara, Manasa Kotina, Jillian L. Pope, Simak Ali, Selina Darling-Reed, Matthew E. Burow, Madhavi Gangapuram, Suresh Eyunni, Jaylen Thomas, Aaron Hilliard, A. Michael Davidson, Elizabeth Henderson, Syreeta L. Tilghman
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2026-07-01
Serija:	Frontiers in Pharmacology
Teme:	breast cancer endocrine resistance estrogen receptor estrogen receptor mutations midasin ribozinoindoles
Online dostop:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1852788/full
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