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Enantiomeric profile of promethazine in metabolic studies in liver microsomes

Promethazine (PMZ) is metabolized in the liver giving rise to chiral metabolites, including promethazine sulfoxide (PMZSO) and desmonomethyl promethazine (DMPMZ). Other metabolites, such as dioxopromethazine (DOPMZ), hydroxy promethazine (PMZOH), N-desmethyl-promethazine sulfoxide, and promethazine...

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Principais autores: Maria Miguel Coelho, Bárbara Silva, Carla Fernandes, Fernando Remião, Maria Elizabeth Tiritan
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2024-11-01
Serier:Journal of Chromatography Open
Fag:
Promethazine
Enantioselectivity
Enantioseparation
Metabolites
Enantiomers
Online adgang:http://www.sciencedirect.com/science/article/pii/S277239172400032X
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