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High-Resolution Magic Angle Spinning Metabolomic Profiling of IDH-Wild-Type Glioblastoma Reveals a Composite Surgical Sampling Signature Shaped by Clinical and Anatomical Tumor Features

Background/Objectives: Tissue-based metabolomic readouts in IDH-wild-type glioblastoma may be strongly shaped by how tumor tissue is surgically accessed and sampled. We aimed to determine whether, and to what extent, surgical sampling context structures the HRMAS metabolic landscape, and to disentan...

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Hoofdauteurs: Julien Todeschi, Caroline Bund, Hassiba Outilaft, Hélène Cebula, Izzie-Jacques Namer
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI AG 2026-04-01
Reeks:Metabolites
Onderwerpen:
glioblastoma
HRMAS NMR
metabolomics
surgical sampling
intratumoral heterogeneity
biopsy
Online toegang:https://www.mdpi.com/2218-1989/16/5/296
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