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The human trophoblast cell-surface antigen 2 (TROP-2) expression on metastasized breast cancer

Abstract Purpose The antibody–drug conjugates (ADCs) sacituzumab govitecan (SG) and datopotamab deruxtecan target trophoblast cell surface antigen 2 (TROP-2) and have shown significant efficacy in HER2-negative metastatic breast cancer (mBC). As TROP-2 may serve as a target across multiple treatment...

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Principais autores: M. Weich, L. Christl, M. Kiesel, J. Salmen, A. Wöckel, J. Diessner, E. Gerhard-Hartmann, T. Schlaiss
Format: Artigo
Sprog:Inglês
Udgivet: Springer 2026-07-01
Serier:Journal of Cancer Research and Clinical Oncology
Fag:
TROP-2
H-score
Longitudinal TROP-2 expression
Breast cancer
Sacituzumab govitecan
Online adgang:https://doi.org/10.1007/s00432-026-06551-4
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