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Sex hormones differently regulate lipid metabolism genes in primary human hepatocytes

Abstract Background Prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) is higher in men than in women. Hormonal and genetic causes may account for the sex differences in MASLD. Current human in vitro liver models do not sufficiently take the influence of biological sex an...

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Autori principali: Lena Seidemann, Clara Paula Lippold, Carolin Marie Rohm, Julian Connor Eckel, Gerda Schicht, Madlen Matz-Soja, Thomas Berg, Daniel Seehofer, Georg Damm
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2024-08-01
Serie:BMC Endocrine Disorders
Soggetti:
Primary human hepatocytes
Sex differences
Hepatic steatosis
MASLD
Sex hormones
17β-estradiol
Accesso online:https://doi.org/10.1186/s12902-024-01663-9
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