Interferon (IFN) and Cellular Immune Response Evoked in RNA-Pattern Sensing During Infection with Hepatitis C Virus (HCV)

Hepatitis C virus (HCV) infects hepatocytes but not dendritic cells (DCs), but DCs effectively mature in response to HCV-infected hepatocytes. Using gene-disrupted mice and hydrodynamic injection strategy, we found the MAVS pathway to be crucial for induction of type III interferons (IFNs) in respon...

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Autori principali:	Masato Nakai, Hiroyuki Oshiumi, Kenji Funami, Masaaki Okamoto, Misako Matsumoto, Tsukasa Seya, Naoya Sakamoto
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2015-10-01
Serie:	Sensors
Soggetti:	Hepatitis C virus (HCV) interferon (IFN)-lambda dendritic cells (DCs) Toll-like receptor 3 (TLR3) natural killer (NK) cell cytotoxic T lymphocyte (CTL)
Accesso online:	http://www.mdpi.com/1424-8220/15/10/27160
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