Aconitase causes iron toxicity in Drosophila pink1 mutants.
The PTEN-induced kinase 1 (PINK1) is a mitochondrial kinase, and pink1 mutations cause early onset Parkinson's disease (PD) in humans. Loss of pink1 in Drosophila leads to defects in mitochondrial function, and genetic data suggest that another PD-related gene product, Parkin, acts with pink1 to reg...
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| Principais autores: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science (PLoS)
2013-04-01
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| Series: | PLoS Genetics |
| Acceso en liña: | http://europepmc.org/articles/PMC3636082?pdf=render |
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