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Gut microbiota and other factors associated with increased T cell regulation in HIV-exposed uninfected infants

IntroductionInfants exposed to HIV and uninfected (HEUs) are at higher risk of infectious morbidity than HIV-unexposed uninfected infants (HUUs). Multiple immune defects of unknown origin were observed in HEUs. We hypothesized that HEUs have more regulatory and inhibitory checkpoint-expressing T cel...

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Furkejuvvon:
Váldodahkkit: Michael J. Johnson, Sarah K. Lazarus, Ashlynn E. Bennett, Adriana Tovar-Salazar, Charles E. Robertson, Jennifer M. Kofonow, Shaobing Li, Bruce McCollister, Marta C. Nunes, Shabir A. Madhi, Daniel N. Frank, Adriana Weinberg
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Frontiers Media S.A. 2025-03-01
Ráidu:Frontiers in Immunology
Fáttát:
regulatory T cells
gut microbiome
human immunodeficiency virus
HIV-exposed uninfected infants
Blautia wexleraea
Klebsiella pneumoniae
Liŋkkat:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1533003/full
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