Systematic Optimization of Proteolysis-Targeting Chimeras for PIN1 Enables Selective Degradation and Antitumor Activity In Vivo

<b>Background</b>: The peptidyl–prolyl cis–trans isomerase PIN1 regulates multiple oncogenic and tumor-suppressive pathways and is frequently overexpressed in human cancers. Although pharmacological inhibition of PIN1 has shown antitumor potential, existing PIN1-targeting degraders lack systematic s...

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Principais autores:	Yuying Ma, Yang Teng, Jinjin Liu, Yuke Deng, Lingbo Xu, Ruichen Gao, Tingyu Peng, Wei Li, Yue Wei, Linfeng Li, Zufeng Guo
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2026-02-01
coleção:	Pharmaceutics
Assuntos:	PIN1 proteolysis-targeting chimeras structure–activity relationship antitumor efficacy
Acesso em linha:	https://www.mdpi.com/1999-4923/18/3/288
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