Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein

Abstract Background Proteolytic processing of the prion protein (PrPC) by endogenous proteases generates bioactive membrane-bound and soluble fragments which may help to explain the pleiotropic roles of this protein in the nervous system and in brain diseases. Shedding of almost full-length PrPC int...

Cijeli opis

Bibliografski detalji

Glavni autori:	Luise Linsenmeier, Behnam Mohammadi, Sebastian Wetzel, Berta Puig, Walker S. Jackson, Alexander Hartmann, Keiji Uchiyama, Suehiro Sakaguchi, Kristina Endres, Jörg Tatzelt, Paul Saftig, Markus Glatzel, Hermann C. Altmeppen
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2018-04-01
Serija:	Molecular Neurodegeneration
Teme:	ADAM10 Antibody Exosomes Glycosylation Membrane anchor Neurodegeneration
Online pristup:	http://link.springer.com/article/10.1186/s13024-018-0248-6
Oznake:	Dodaj oznaku Bez oznaka, Budi prvi tko označuje ovaj zapis!