Selective sweep for an enhancer involucrin allele identifies skin barrier adaptation out of Africa

Selection on alleles contributing to human evolution is not well understood. Here, the authors investigate positive selection on skin barrier adaptation, identifying a selective sweep on involucrin alleles associated with migration out of Africa, and confirming enhancer regulatory effects with funct...

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Hlavní autoři:	Mary Elizabeth Mathyer, Erin A. Brettmann, Alina D. Schmidt, Zane A. Goodwin, Inez Y. Oh, Ashley M. Quiggle, Eric Tycksen, Natasha Ramakrishnan, Scot J. Matkovich, Emma Guttman-Yassky, John R. Edwards, Cristina de Guzman Strong
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2021-05-01
Edice:	Nature Communications
On-line přístup:	https://doi.org/10.1038/s41467-021-22821-w
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