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Chronic unpredicted mild stress-induced depression alter saxagliptin pharmacokinetics and CYP450 activity in GK rats

Background. This study was to explore the pharmacokinetics of saxagliptin (Sax) in Goto–Kakizaki (GK) rats complicated with depression induced by chronic unpredicted mild stress (CUMS). The comorbidity of diabetic patients with depression is becoming more and more epidemic. Whether depression mental...

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Main Authors: Zhengchao Xia, Hongyan Wei, Jingjing Duan, Ting Zhou, Zhen Yang, Feng Xu
Format: Artigo
Language:Inglês
Published: PeerJ Inc. 2016-01-01
Series:PeerJ
Subjects:
Pharmacokinetics
Depression
Diabetes
CUMS
Saxagliptin
Rat
Online Access:https://peerj.com/articles/1611.pdf
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