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The role of the molecular chaperone heat shock protein A2 (HSPA2) in regulating human sperm-egg recognition

One of the most common lesions present in the spermatozoa of human infertility patients is an idiopathic failure of sperm-egg recognition. Although this unique cellular interaction can now be readily by-passed by assisted reproductive strategies such as intracytoplasmic sperm injection (ICSI), recen...

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Principais autores: Brett Nixon, Elizabeth G Bromfield, Matthew D Dun, Kate A Redgrove, Eileen A McLaughlin, R John Aitken
Formato: Artigo
Idioma:Inglês
Publicado: Wolters Kluwer Medknow Publications 2015-01-01
Series:Asian Journal of Andrology
Assuntos:
gene regulation
Musashi
Musashi-1
Musashi-2
posttranscriptional control
RNA binding proteins
spermatogenesis
splicing
testis
translation
cell fate
cell stress
importin
karyopherin
nucleocytoplasmic transport
spermatid
spermatocyte
artificial insemination
biomarker
fertility
fertilization
flow cytometry
infertility
nanotechnology
oocyte activation
Postacrosomal Sheath WWI Domain Binding Protein
sperm
SPTRX3
thioredoxin
ubiquitin
ATP binding cassette transporters
albumin
high-density lipoprotein
lipid rafts
membrane fluidity
membrane microdomains
membrane packing
oxysterols
reverse cholesterol transport
sterol transporters
egg
heat shock protein A2
molecular chaperone
sperm-egg interactions
Acceso en liña:http://www.ajandrology.com/article.asp?issn=1008-682X;year=2015;volume=17;issue=4;spage=568;epage=573;aulast=Nixon
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