Disruption of metabolic licensing by JAK inhibitors constrains CD8 T cell activation and effector function

Abstract Janus kinase inhibitors (JAKis) are widely prescribed for autoimmune diseases, but their use is associated with increased infection risk. The mechanisms underlying this susceptibility remain unclear. CD8 T cells play a central role in antimicrobial defence, yet little is known about how JAK...

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Hlavní autoři:	Luisina Inés Onofrio, Carolina Abrate, Ingrid Strusberg, Liliana Morales, Danilo Guillermo Ceschin, Carolina Lucía Montes, Cinthia Carolina Stempin, Eva Acosta Rodríguez
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Publishing Group 2026-03-01
Edice:	Cell Death and Disease
On-line přístup:	https://doi.org/10.1038/s41419-026-08610-7
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